Publications

Research papers

Details Matter: noise and model structure set the relationship between cell size and cell cycle timing

Felix Barber; Po-Yi Ho; Andrew Murray; Ariel Amir
Accepted Frontiers in Cell and Developmental Biology (2017)

Exploring Genetic Suppression Interactions on a Global Scale

Jolanda van Leeuwen; Carles Pons; Joseph C Mellor; Takafumi N Yamaguchi; Helena Friesen; John H Koschwanez; Mojca Mattiazzi Ušaj; Maria Pechlaner; Mehmet Takar; Matej Ušaj; Benjamin VanderSluis; Kerry Andrusiak; Pritpal Bansal; Anastasia Baryshnikova; Claire E Boone; Jessica Cao; Atina Cote; Marinella Gebbia; Gene Horecka; Ira Horecka; Elena Kuzmin; Nicole Legro; Wendy Liang; Natascha van Lieshout; Margaret McNee; Bryan-Joseph San Luis; Fatemeh Shaeri; Ermira Shuteriqi; Son Sun; Lu Yang; Ji-Young Youn; Michael Yuen; Michael Costanzo; Anne-Claude Gingras; Patrick Aloy; Chris Oostenbrink; Andrew W Murray; Todd R Graham; Chad L Myers; Brenda J Andrews; Frederick P Roth; Charles Boone
Science 354 (6312), pp. aag0839 (2016)
Journal PubMed

Multicellularity Makes Somatic Differentiation Evolutionarily Stable

Mary E Wahl; Andrew W Murray

PNAS 113 (30), pp. 8362–8367 (2016)

Publications

Research papers

Details Matter: noise and model structure set the relationship between cell size and cell cycle timing

Exploring Genetic Suppression Interactions on a Global Scale

Multicellularity Makes Somatic Differentiation Evolutionarily Stable

Spatially Constrained Growth Enhances Conversional Meltdown

A Predictive Model for Yeast Cell Polarization in Pheromone Gradients

How Obstacles Perturb Population Fronts and Alter Their Genetic Structure

Evolutionary adaptation after crippling cell polarization follows reproducible trajectories

Evolving a 24-hour oscillator in budding yeast

Conservation Weighting Functions Enable Covariance Analyses to Detect Functionally Important Amino Acids

Chromosomal attachments set length and microtubule number in the S. cerevisiae mitotic spindle

A Model for Cell Wall Dissolution in Mating Yeast Cells: Polarized Secretion and Restricted Diffusion of Cell Wall Remodeling Enzymes Induces Local Dissolution

Tethering Sister Centromeres to Each Other Suggests the Spindle Checkpoint Detects Stretch within the Kinetochore

A Model for the Evolution of Biological Specificity: a Cross-Reacting DNA-Binding Protein Causes Plasmid Incompatibility

Niche Engineering Demonstrates a Latent Capacity for Fungal-Algal Mutualism

Growing yeast into cylindrical colonies

Genetic drift opposes mutualism during spatial population expansion

Genetically engineered transvestites reveal novel mating genes in budding yeast

Nutrient shielding in clusters of cells

Improved use of a public good selects for the evolution of undifferentiated multicellularity

Mad2 and Mad3 Cooperate to Arrest Budding Yeast in Mitosis

Selective sweeps in growing microbial colonies

Asymmetry in Sexual Pheromones Is Not Required for Ascomycete Mating

Sucrose Utilization in Budding Yeast as a Model for the Origin of Undifferentiated Multicellularity

Reduced Mad2 expression keeps relaxed kinetochores from arresting budding yeast in mitosis

Mutation Rates across Budding Yeast Chromosome VI Are Correlated with Replication Timing

Seeing mutations in living cells

Rapid Expansion and Functional Divergence of Subtelomeric Gene Families in Yeasts

Recruiting a microtubule-binding complex to DNA directs chromosome segregation in budding yeast

Coding-sequence determinants of gene expression in Escherichia coli

The cost of gene expression underlies a fitness trade-off in yeast

Estimating the per-base-pair mutation rate in the yeast Saccharomyces cerevisiae

Budding yeast mitotic chromosomes have an intrinsic bias to biorient on the spindle

The spindle checkpoint rescues the meiotic segregation of chromosomes whose crossovers are far from the centromere

Positive-Feedback Loops as a Flexible Biological Module

The Speed of Evolution and Maintenance of Variation in Asexual Populations

Ploidy controls the success of mutators and nature of mutations during budding yeast evolution

Anaphase inactivation of the spindle checkpoint

High-Resolution Mutation Mapping Reveals Parallel Experimental Evolution in Yeast

Experimental evolution of mating discrimination in budding yeast

A small-molecule inhibitor of Mps1 blocks the spindle-checkpoint response to a lack of tension on mitotic chromosomes

Identification of xenopus CENP-A and an associated centromeric DNA repeat

The centromeric protein Sgo1 is required to sense lack of tension on mitotic chromosomes

Spindle checkpoint component Mad2 contributes to biorientation of homologous chromosomes

Spo13 protects meiotic cohesin at centromeres in meiosis I

Mutation of YCS4, a budding yeast condensin subunit, affects mitotic and nonmitotic chromosome behavior

The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint

Genes involved in sister chromatid separation and segregation in the budding yeast Saccharomyces cerevisiae

Lack of tension at kinetochores activates the spindle checkpoint in budding yeast

Visualization of Mad2 dynamics at kinetochores, along spindle fibers, and at spindle poles in living cells

The Xenopus chromokinesin Xkid is essential for metaphase chromosome alignment and must be degraded to allow anaphase chromosome movement

Requirement of the spindle checkpoint for proper chromosome segregation in budding yeast meiosis

Cdc28 activates exit from mitosis in budding yeast

Phosphorylation by Cdc28 activates the Cdc20-dependent activity of the anaphase-promoting complex

MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p, Cdc20p, and Mad2p

The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins

Genetic selection of peptide inhibitors of biological pathways

Mad2 binding by phosphorylated kinetochores links error detection and checkpoint action in mitosis

Lesions in many different spindle components activate the spindle checkpoint in the budding yeast Saccharomyces cerevisiae

The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast

Time-lapse microscopy reveals unique roles for kinesins during anaphase in budding yeast

Dynamics of centromeres during metaphase-anaphase transition in fission yeast: Dis1 is implicated in force balance in metaphase bipolar spindle

Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores

Microinjection of antibody to Mad2 protein into mammalian cells in mitosis induces premature anaphase

Localization of Mad2 to kinetochores depends on microtubule attachment, not tension

Budding yeast Cdc20: a target of the spindle checkpoint

Interphase chromosomes undergo constrained diffusional motion in living cells

A novel yeast screen for mitotic arrest mutants identifies DOC1, a new gene involved in cyclin proteolysis

Chromosome and low copy plasmid segregation in E. coli: visual evidence for distinct mechanisms

Mitosis in living budding yeast: anaphase A but no metaphase plate

Mitochondrial transmission during mating in Saccharomyces cerevisiae is determined by mitochondrial fusion and fission and the intramitochondrial segregation of mitochondrial DNA

In vivo localization of DNA sequences and visualization of large-scale chromatin organization using lac operator/repressor recognition

GFP tagging of budding yeast chromosomes reveals that protein-protein interactions can mediate sister chromatid cohesion

Protein phosphatase 2A regulates MPF activity and sister chromatid cohesion in budding yeast

Real time observation of anaphase in vitro

Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores

Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption

Aberrantly segregating centromeres activate the spindle assembly checkpoint in budding yeast

Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast