The role of cyclin synthesis and degradation in the control of maturation promoting factor activity
Publication information:
AW Murray, Solomon, and Kirschner. 1989. “The Role of Cyclin Synthesis and Degradation in the Control of Maturation Promoting Factor Activity”. Nature, 339, 6222, Pp. 280-6. doi:10.1038/339280a0
Abstract
We show that cyclin plays a pivotal role in the control of mitosis. A proteolysis-resistant mutant of cyclin prevents the inactivation of maturation promoting factor and the exit from mitosis both in vivo and in vitro. We have used a fractionated extract to study the activation of MPF by added cyclin protein.